Ethnomedicinal and cytotoxicity study of plants used by Dumagat Tribe in Philippines
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Abstract. Domingo MLM, Gabales M, Guerra DAA, Lindo JSRM, Brillo SC. 2024. Ethnomedicinal and cytotoxicity study of plants used by Dumagat Tribe in Philippines. Asian J Ethnobiol 7: 90-104. Many indigenous tribes lack access to modern medicine and rely on ethnomedicinal plants to treat various medical conditions. This study documented the ethnomedicinal knowledge and practices of the Dumagats in Barangays San Lorenzo, Norzagaray, and Kabayunan, Doña Remedios Trinidad, Bulacan, Philippines. The study identified 22 ethnomedicinal plants used to treat everyday ailments, with leaves being the most frequently utilized plant part, typically decocted and taken orally. Eighteen out of 22 (68.18%) of the plants were identified to be native to the Philippines: Alstonia scholaris, Homalomena philippinensis, Blumea balsamifera, Combretum indicum, Dillenia philippinensis, Pterocarpus indicus, Flagellaria indica, Cyrtandra incisa, Leea philippinensis, Lagerstroemia speciosa, Saccharum spontaneum, Embelia philippinensis, Antidesma bunius, and Buddleja asiatica highlight the predominance of native plants in the area and its utilization by the tribe. The most frequently used plants were Artemisia vulgaris, B. balsamifera, S. spontaneum, and D. philippinensis, with a use value 0.57. The results shed light on the pharmacological characteristics of plant extracts from A. vulgaris, C. amboinicus, and B. balsamifera using brine shrimp lethality and trypan blue assays. Examination of concentration and time-dependent effects revealed cytotoxic properties. Higher concentrations (1 mg/mL) significantly reduced cell viability, while lower concentrations (100 and 10 micrograms/mL) showed varied responses; prolonged exposure exacerbated cytotoxic effects. These findings underscored the importance of documenting ethnomedicinal practices and assessing the cytotoxicity of medicinal plants to understand their potential health impacts, providing practical insights for researchers, botanists, and healthcare professionals interested in ethnomedicine and pharmacology.
2018-01-01
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