Toxicity of Randia nilotica fruit extract on Schistosoma mansoni, Biomphalaria pfeifferi and Bulinus truncatus

Abstract

Abstract. Ebodi AYE, Ahmed MM. 2017. Toxicity of Randia nilotica fruit extract on Schistosoma mansoni, Biomphalaria pfeifferi and Bulinus truncatus. Cell Biol Dev 1 (1): 23-30. The aqueous filtered and unfiltered extract of the fruits of Randia nilotica (locally named Shagarat El-Murfaein) were assessed as molluscicides against Biomphalaria pfeifferi and Bulinus truncatus, as well as their effect on cercariae and miracidia of Schistosoma mansoni. The plant was tested on uninfected B. pfeifferi and B. truncatus, and the results showed that unfiltered extracts were found to be relatively more potent than filtered ones (i.e., 100% was attained at 90 ppm and 80 ppm), respectively. The filtered extract was tested on uninfected B. pfeifferi and B. truncatus (100% was attained at 100 ppm and 90 ppm), respectively. The effect of the unfiltered extract on infected B. pfeifferi produced 100% mortality in a concentration of 70 ppm. The activity of the plant on cercariae and miracidia revealed that cercariae were more resistant than miracidia (i.e.50 ppm killed all cercariae within 3 hours while killed miracidia within 2 hours. The results were statistically analyzed and discussed, and the findings were promising and could open new avenues for the practical use of the plant in the field.