Pengaruh ekstrak air talas (Colocasia esculenta) pada nilai indeks eritrosit mencit jantan (Mus musculus) terinfeksi skabies
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Abstrak. Widhyastini IGAM, Yuliani N, Azizah DASN, Azizah M, Wulandari IGAI. 2024. Pengaruh ekstrak air talas (Colocasia esculenta) pada nilai indeks eritrosit mencit jantan (Mus musculus) terinfeksi skabies. Pros Sem Nas Masy Biodiv Indon 10: 104-109. Skabies merupakan penyakit tropis pada hewan yang disebabkan oleh parasit Sarcoptes scabiei. Beberapa tanaman berpotensi sebagai antiskabies, namun penelitian terhadap tanaman yang dapat melawan skabies masih terbatas. Colocasia esculenta (talas) merupakan tanaman yang mudah tumbuh dengan aplikasi sebagai tanaman obat yang luas. Penelitian terhadap aplikasi C. esculenta sebagai antiskabies masih perlu dikaji. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak air C. esculenta pada nilai indeks eritrosit mencit jantan terinfeksi skabies. Penelitian ini merupakan penelitian eksperimental dengan 6 perlakuan (A: ekstrak air talas 100 g/100 mL air, B: ekstrak air talas 200 g/100 mL air, C: ekstrak air talas 300 g/100 mL air, D: kontrol negatif (air saja), E: kontrol positif (Ivermectin), F: kontrol normal (tidak diinfeksi skabies, tidak diberikan perlakuan) dengan tiga kelompok yang diuji (keadaan sehat, saat terinfeksi, setelah perlakuan). Bagian batang dan daun C. esculenta diekstraksi dengan pelarut air, ekstrak dioleskan pada bagian yang terinfeksi skabies selama 5 hari pengamatan dan dilakukan hingga hari ke 7. Aktivitas antiskabies ditentukan dengan analisis profil darah mencit jantan (Mus musculus), nilai indeks eritrosit yang diamati meliputi nilai indek MCV, MCH dan MCHC menggunakan hematology analyzer. Data yang diperoleh dianalisis dengan ANOVA single factor dan dilanjutkan uji T menggunakan SPSS. Nilai indek MCV dan MCH memperlihatkan adanya perbedaan yang signifikan antara kelompok mencit sehat, mencit saat terinfeksi dan mencit setelah perlakuan. Sedangkan nilai indek MCHC tidak menunjukkan perbedaan yang signifikan. Penelitian ini menunjukkan bahwa C. esculenta dapat berpotensi sebagai antiskabies topikal.
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