Distribution, morphology, phytochemical composition, and antioxidant activity of Mediasia macrophylla (Apiaceae) from the Western Tien Shan, Kazakhstan
Article Sidebar
Abstract Views: 306
File Views: 159
Main Article Content
Abstract
Abstract. Ubaev FA, Esimova AM, Aimenova ZE, Iskakova ZB, Kolpek A, Tekebayeva ZB, Bazarkhankyzy A, Askarova N. 2026. Distribution, morphology, phytochemical composition, and antioxidant activity of Mediasia macrophylla (Apiaceae) from the Western Tien Shan, Kazakhstan. Biodiversitas 27 (3): d270315. https://doi.org/10.13057/biodiv/d270315. Mediasia macrophylla (Apiaceae) is a perennial Central Asian species with reported medicinal relevance; however, integrated ecological, morphological, and phytochemical data for populations in Kazakhstan remain limited. The present study provides a preliminary, exploratory, site-based characterization of M. macrophylla from two natural populations within the Aksu-Zhabagly State Nature Reserve (Western Tien Shan, southern Kazakhstan). Habitat conditions, quantitative morphology, essential oil composition, and antioxidant activity of solvent extracts were assessed. Field surveys confirmed that the species occurs in restricted, localized populations associated with rocky limestone slopes and meadow-steppe habitats. Quantitative morphometric analysis of mature, flowering individuals (n = 20) showed moderate variation in vegetative traits and comparatively conservative reproductive and fruit morphology, consistent with stable diagnostic morphology at the local population level. Essential oil composition was determined by GC-MS using a single pooled sample, revealing 29 compounds accounting for 95.83% of the total oil. Antioxidant activity of pooled solvent extracts was evaluated using FRAP and DPPH assays with technical replication. Phytochemical and antioxidant data were obtained from pooled material and technical replicates only and are therefore interpreted descriptively. A clear solvent-dependent pattern was observed: the ethyl acetate extract showed the highest Ferric Reducing Capacity (FRAP absorbance 1.17 at 1.0 mg/mL), whereas the ethanol extract exhibited the strongest radical scavenging activity (80.62% DPPH inhibition at 1.0 mg/mL), approaching that of gallic acid (86.14%). The chloroform extract displayed consistently weak activity. Overall, the results provide descriptive, hypothesis-generating data on the ecological context, morphology, and phytochemical and antioxidant profiles of M. macrophylla within the Aksu-Zhabagly Reserve and highlight the need for replicated, multi-site, and multi-season studies to assess population-level variability and potential chemotypic patterns.
Article Details
Issue
Section
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
An Q, Ren JN, Li X, Fan G, Qu SS, Song Y, Li Y, Pan SY. 2021. Recent updates on bioactive properties of linalool. Food funct 12 (21): 10370-10389. https://doi.org/10.1039/d1fo02120f.
Bahadori MB, Dinparast L, Zengin G. 2016. The genus Heracleum: A comprehensive review on its phytochemistry, pharmacology, and ethnobotanical values as a useful herb. Compr Rev Food Sci Food Saf 15 (6): 1018-1039. https://doi.org/10.1111/1541-4337.12222.
Bahora N, Abdukodir M, Nurali M, Nigina F, Tursunmurod D, Asatillo R, Sabina K. 2026. GC-MS Analysis of essential oil isolated from Mediasia macrophylla Pimen plants. Cent Asian J Med Nat Sci 7 (1): 243-247. https://doi.org/10.51699/cajmns.v7i1.3040.
Baser KHC, Özek T, Nuriddinov KR, Nigmatullaev AM, Khadzimatov KK, Aripov KN. 1997. Essential oils of Mediasia macrophylla (Regel et Schmalh.) Pimen. and Foeniculum vulgare Mill. from Uzbekistan. J Essent Oil Res 9 (2): 249-250. https://doi.org/10.1080/10412905.1997.9699474.
Benzie IFF, Devaki M. 2018. The ferric reducing/antioxidant power (FRAP) assay for non‐enzymatic antioxidant capacity: Concepts, procedures, limitations and applications. Measurement of Antioxidant Activity and Capacity: Recent Trends and Applications. John Wiley and Sons Ltd, Chichester. https://doi.org/10.1002/9781119135388.ch5.
Bouchra S-A, Thierry T, Zeinab S, Akram H, Othmane M. 2017. The Apiaceae: Ethnomedical family as source for industrial uses. Industrial crops and products 109: 661-671. https://doi.org/10.1016/j.indcrop.2017.09.027.
Changxing L, Dongfang D, Lixue Z, Saeed M, Alagawany M, Farag MR, Chenling M, Jianhua L. 2019. Heracleum persicum: Chemical composition, biological activities and potential uses in poultry nutrition. Worlds Poult Sci J 75 (2): 207-218. https://doi.org/10.1017/S0043933919000205.
Chernenko TV, Glushenkova AI, Nigmatullaev AM. 2002. Lipids from Mediasia macrophylla leaves. Chem Nat Compd 38: 307-309. https://doi.org/10.1023/A:1021657520719.
Chernenko TV, Glushenkova AI. 2003. Unsaponified compounds and unsaturated fatty acids of lipids from Mediasia macrophylla leaves. Chem Nat Compd 39: 158-160. https://doi.org/10.1023/A:1024801611488.
Crestani G, Cunningham N, Csepregi K, Badmus U, Jansen M. 2023. From stressor to protector, UV-induced abiotic stress resistance. Photochem Photobiol Sci 22 (9): 2189-2204. https://doi.org/10.1007/s43630-023-00441-1.
da Silva LRR, Ferreira OO, Cruz JN, de Jesus Pereira Franco C, dos Anjos TO, Cascaes MM, de Costa WA, de Aguiar Andrade EH, de Oliveira MS. 2021. Lamiaceae essential oils: Phytochemical profile, antioxidant and biological activities. Evid Based Complement Alternat Med 2021: 6748052. https://doi.org/10.1155/2021/6748052.
Das G, Das S, Talukdar AD, Venil CK, Bose S, Banerjee S, Shin HS. 2023. Pharmacology and ethnomedicinal potential of selected plants species from Apiaceae (Umbelliferae). Comb Chem High Throughput Screen 26 (2): 256-288. https://doi.org/10.2174/1386207325666220406110404.
Elangovan S, Mudgil P. 2023. Antibacterial properties of Eucalyptus globulus essential oil against MRSA: A systematic review. Antibiotics 12 (3): 474. https://doi.org/10.3390/antibiotics12030474.
Gulcin I. 2020. Antioxidants and antioxidant methods: An updated overview. Archives Toxicol 94 (3): 651-715. https://doi.org/10.1007/s00204-020-02689-3.
Gulcin I, Alwasel SH. 2023. DPPH radical scavenging assay. Processes 11 (8): 2248. https://doi.org/10.3390/pr11082248.
Gyrdymova YV, Rubtsova SA. 2022. Caryophyllene and caryophyllene oxide: A variety of chemical transformations and biological activities. Chem Pap 76: 1-39. https://doi.org/10.1007/s11696-021-01865-8.
Herden T, Friesen N. 2019. Ecotypes or phenotypic plasticity—The aquatic and terrestrial forms of Helosciadium repens (Apiaceae). Ecol Evol 9 (24): 13954-13965. https://doi.org/10.1002/ece3.5833.
Iskakova Z, Kozhantayeva A, Tazhkenova G, Mashan T, Tosmaganbetova K, Tashenov Y. 2022. Investigation of chemical constituents of Chamaenerion latifolium L. Anti-Inflamm Anti-Allergy Agents Med Chem 21 (3): 173-178. https://doi.org/10.2174/1871523022666221125111235.
Kozhantayeva A, Iskakova Z, Ibrayeva M, Sapiyeva A, Arkharbekova M, Tashenov Y. 2025. Phytochemical insights and therapeutic potential of Chamaenerion angustifolium and Chamaenerion latifolium. Molecules 30 (5): 1186. https://doi.org/10.3390/molecules30051186.
Kozhantayeva A, Tursynova N, Kolpek A, Aibuldinov Y, Tursynova A, Mashan T, Mukazhanova Z, Ibrayeva M, Zeinuldina A, Nurlbayeva A, Iskakova Z, Tashenov Y. 2024. Phytochemical profiling, antioxidant and antimicrobial potentials of ethanol and ethyl acetate extracts of Chamaenerion latifolium L. Pharmaceuticals 17 (8): 996. https://doi.org/10.3390/ph17080996.
Kurimoto S-I, Okasaka M, Kashiwada Y, Kodzhimatov OK, Takaishi Y. 2010. A C14-polyacetylenic glucoside with an α-pyrone moiety and four C10-polyacetylenic glucosides from Mediasia macrophylla. Phytochemistry 71 (5-6): 688-692. https://doi.org/10.1016/j.phytochem.2009.12.007.
Pedrali A, della Cuna FSR, Grisoli P, Corti M, Brusotti G. 2019. Chemical composition and antimicrobial activity of the essential oil from the bark of Xylopia hypolampra. Nat Prod Commun 14 (6): 1-5. https://doi.org/10.1177/1934578X19857022.
Salehi B, Mishra AP, Shukla I, Sharifi-Rad M, del Mar Contreras M, Segura-Carretero A, Fathi H, Nasrabadi NN, Kobarfard F, Sharifi-Rad J. 2018. Thymol, thyme, and other plant sources: Health and potential uses. Phytother Res 32 (9): 1688-1706. https://doi.org/10.1002/ptr.6109.
Singh RP, Gangadharappa HV, Mruthunjaya K. 2017. Cuminum cyminum —a popular spice: An updated review. Pharmacogn J 9 (3): 292-301. https://doi.org/10.5530/pj.2017.3.51.
Stashenko EE, Martinez JR. 2017. Identification of essential oil components. Essential Oils in Food Processing: Chemistry, Safety and Applications. John Wiley and Sons, Ltd, Chichester, UK. https://doi.org/10.1002/9781119149392.ch3.
Suntar I. 2020. Importance of ethnopharmacological studies in drug discovery: Role of medicinal plants. Phytochem Rev 19 (5): 1199-1209. https://doi.org/10.1007/s11101-019-09629-9.
Topal M, Sarıkaya SBO, Topal F. 2021. Determination of Angelica archangelica’s antioxidant capacity and mineral content. ChemistrySelect 6: 7976-7980. https://doi.org/10.1002/slct.202102282.
Zhumanova M, Wrage-Mönnig N, Jurasinski G. 2021. Long-term vegetation change in the Western Tien-Shan Mountain pastures, Central Asia, driven by a combination of changing precipitation patterns and grazing pressure. Sci Total Environ 781: 146720. https://doi.org/10.1016/j.scitotenv.2021.146720.