Hypoglycaemic and hypolipidaemic activities of water extract of Lagerstroemia speciosa (L.) Pers. leaves in diabetic rat

Abstract

Abstract. The aim of this study was to know the hypoglycaemic and hypolipidaemic activities of water extract of bungur (Lagerstroemia speciosa [L.] Pers.) leaves in alloxan-induced diabetic rats. Phytochemical studies were conducted to determine the tannin-contents of the water extract (WE). Male Wistar rats (150- 180 9 BW) were used in this study. The rats were divided into six groups: normal control; diabetic control; glibenclamide; WE 0.1 g/200 9 BW; WE 0.2 g/200 9 BW; and WE 0.5 g/200 9 BW. Dried leaves of bungur extracted with boiling water (50 g/L) for 30 minutes. The extract was administered orally. Fasting blood glucose, triglyceride, and total cholesterol were determined at 0, 2, 4, 6 hours after treatment. Total phenol, ellagitannin, gallotannin, and condensed-tannin were determined from the WE. The results showed that WE exhibited hypoglycemic activity at doses 0.2 g/200 9 BW and 0.5 g/200 9 BW. The last dose showed similar hypoglycemic activity compared with glibenclamide. All doses showed hypolipidemic activity higher than glibenclamide. Phytochemical studies showed that the WE containing total phenol 0.025%; ellagitannin 0.011%; gallotannin 0.0199%; and condensed-tannin 0.0167%.