Abstract. Olatunde OA, Jegede HO, Ameen SA. 2021. Hematological, serum biochemical and histopathological effects of selected herbs and combinations on Trypanosoma brucei infected West African dwarf sheep. Asian J Nat Prod Biochem 19: 10-16. The present work was carried out to study the hematological, serum biochemical and histopathological effects of selected herbal diets on trypanosome infected West African dwarf sheep. Five herbal incorporated diets were tested where A is control diet, B is Citrus aurantifolia; C is Ocimum gratissimum, D is Vernonia amygdalina + Citrus aurantifolia and E is Ocimum gratissimum + Vernonia amygdalina. Sheep on Diets E, A, C, B, and D consumed 856.4g/d, 830g/d, 750.0g/d. 734.0g/d and 687.0g/d respectively showing more acceptability to diet E. Additionally, sheep on Diet E was highest in RBC, WBC, Hb, lymphocyte, PCV and basophils. The least hematological indices were recorded for the animals on Control diet (A) showing that all herbal diets improved blood indices of the infected sheep. The ALP concentration was significantly different (17.000i.u/l) in Diet B compared to other Diets while the least ALP was noted for sheep on Diets A and B. Herbs and combinations used in this study significantly improved both hematological and pathological lesions seen in experimental trypanosomosis caused by Trypanosoma brucei infection in sheep. Best results were gotten from Diet E combinations.
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