Abstract. Nenotek PS, Londingkene JA, Ludji R, Harini TS, Kapa MJ, Nguru ESO, Roefaida E, Konanin M. 2022. The toxicity of Annona squamosa seeds and Anacardium occidentale seed shell from East Nusa Tenggara, Indonesia, against cabbage caterpillar (Crocidolomia pavonana). Intl J Trop Drylands 6: 39-44. The study objective was to determine the effect of methanol extracts of Annona squamosa L. seeds and seed coat of Anacardium occidentale L. from East Nusa Tenggara, Indonesia on the Crocidolomia pavonana (Fabricius, 1794), cabbage caterpillar. Bioassay was done using with a residue method in feed for one minute at each concentration of A. squamosa seed extract (0.01%; 0.03%; 0.06%; 0.125%; 0.25%; and control) and extract A. occidentale (0.06%; 0.125%; 0.25%; 0.5%; 1%; and control). The results showed that the methanol extract of A. squamosa seeds was more toxic to C. pavonana larvae compared to the methanol extract of A. occidentale. The LC50 and LC95 values of A. squamosa seed extract against the tested insects were 0.04% and 0.16%.