The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

##plugins.themes.bootstrap3.article.main##

RICO RAMADHAN
PREECHA PHUWAPRAISIRISAN
RUDIANTO AMIRTA
MUHAMMAD FADIL BAGAS DARMAWAN
KAUTSAR UL-HAQ
IRAWAN WIJAYA KUSUMA
HERY SUWITO
NURLITA ABDULGANI
AHMAD MUKHDLOR
SAPARWADI

Abstract


Abstract. Ramadhan R, Phuwapraisirisan P, Amirta R, Darmawan MFB, Ul-Haq K, Kusuma IW, Suwito H, Abdulgani N, Mukhdlor A, Saparwadi. 2022. The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengersBiodiversitas 232225-2231Ten ethnomedicinal plant extracts from East Kalimantan flora, traditionally used to treat blood sugar levels and other diabetes-related diseases, were examined in vitro for their antidiabetic and free radical scavenging activities by inhibiting rat alpha-glucosidase and several free radicals such as DPPH, ABTS, and Nitric oxide respectively. Out of the ten plant species investigated for their antidiabetic activity against maltase and sucrase rat alpha-glucosidase, three exhibited the strongest ?-glucosidaseinhibitory activity with maltose as a substrate, namely extracts of Garcinia nervosa, Syzygium caudatilimbum, and Shorea balangeran with IC50 values of 0.046; 0.037; 0.045 mg/mL. Meanwhile, quercetin as a positive control appeared to have a comparable IC50value. Furthermore, among the ten extracts, Syzygium caudatilimbum, Shorea balangeran, and Ixora javanica showed good inhibition against sucrase rat alpha-glucosidase. Moreover, the antioxidant test showed that the ten methanol extracts of plants from East Kalimantan have an antioxidant activity indicated by IC50values. The present study confirms that the ethnopharmacological use of selected plants from East Kalimantan might have potential as an antidiabetic and natural antioxidant.


##plugins.themes.bootstrap3.article.details##

References
Anila L, Hashim MS. Evaluation of in vitro anti-diabetic activity of methanolic extract of Ixora coccinea flowers. J Pharm Sci Res 11: 2367-2372.
Asgar MA. 2013. Anti-diabetic potential of phenolic compounds: A review. Int J Food Prop 16: 91-103.
Casado R, Landa A, Calvo JJ, Terencio MC, Calvo MI. 2010. Anti-inflammatory and antioxidant activities of Jungia paniculate. Pharma Biol 48: 897-905.
Dontha S, Kamurthy H, Mantripragada. 2015. Phytochemical and pharmacological profile of Ixora: A review. Int J Pharm Sci Res 6: 567-584.
Duarte AM, Guarino MP, Barroso S, Gil MM. 2020. Phytopharmacological strategies in the management of type 2 diabetes mellitus. Foods 9: 1-31.
Falah F, Hadiwibowo N. 2017. Species identification of traditional medicine plants for women’s health in East Kalimantan: Lesson learned from local wisdom. Indones J For Res 4: 49-67.
Habu JB and Ibeh BO. 2015. In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract. Biol Rest 48: 1-10.
Hazra B, Biswas S, Mandal N. 2008. Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complement Altern Med 8: 1-10.
Hilla MB, Omri A, Jannet HB, Lamari A, Aouni M, Selmi B. 2013. Phenolic composition, antioxidant and anti-acetylcholinesterase activities of the Tunisian Scabiosa arenaria. Pharm Biol 51: 525-532.
Hossai U, Das AK, Ghosh S, Sil PC. 2020. An overview on the role of bioactive ?-glucosidase inhibitors in ameliorating diabetic complications. Food Chem Toxicol 145: 111738.
Indrianingsih AW, Tachibana S, Itoh K. 2015. In vitro evaluation of antioxidant and ?-glucosidase inhibitory assay of several tropical and subtropical plants. Procedia Environ Sci 28: 639-648.
Jabit ML, Wahyuni FS, Khalid R, Israf DA, Shaari K, Lajis NH, Stanslas J. Cytotoxic and nitric oxide inhibitory activities of methanol extracts of Garcinia species. 47: 1019-1026.
Ji Y, Liu D, Jin Y, Zhaou J, Zhao J, Li H, Li L, Zhang H, Wang H. 2021. In vitro and in vivo inhibitory effect of anthocyanin-rich bilberry extract on ?-glucosidase and ?-amylase. LWT 145: 111484.
Joshi L., Wijaya K, Sirait M., and Mulyoutami E. 2004. Indigenous systems and ecological knowledge among Dayak people in Kutai Barat, East Kalimantan–a preliminary report. ICRAF Southeast Asia Working Paper.
Kim HR, Antonisamy P, Kim YS, Lee G, Ham HD, Kwon KB. 2022. Inhibitory effect of Amomum villosum water extracts on ?-glucosidase activity. Physiol Mol Plant Pathol 117: 101779.
Kissinger, Yamani A, Pitri RMN. ?-Glucosidase inhibitory activity of Shorea belangeran of kerangas forest. Res J Med Plants 10: 356-361.
Li YQ, Zhou FC, Gao F, Bian JS, Shan F. 2009. Comparative evaluation of quecertin, isoquecertin and rutin as inhibitors of ?-glucosidase. J Agric Food Chem 57: 11463-11468.
Manarahan T, Appleton D, Cheng HM, Palanisanny UD. 2012. Flavonoids isolated from Syzygium aqueum leaf extract as potential antihyperglycaemic agents. Food Chem 132: 1802-1807.
Maniyar Y, Bhixavatimath P, Agashikar NV. 2010. Antidiarrheal activity of flowers of Ixora coccinea Linn in rats. J Ayurveda Integr Med 1: 287-291.
Mayori A. 2017. Elephantorrhiza elephantina: Traditional uses, phytochemistry, and pharmacology of an important medicinal plant species Southern Africa. Evid Based Complementary Altern Med 2017: 1-18.
Metasari S, Elfita, Muharni, Yohandini H. 2020. Antioxidant compounds from the stem bark of Syzygium samarangense L. Molekul 15: 175-183.
Mudau TE, Olowoyo JO, Amoo SO. 2022. Etnobotanical assessment of medicinal plants used traditionally for treating diabetes in Vhembe district, Limpopo Province, South Africa. S Afr J Bot 146: 304-324.
Nipun TS, Khatib A, Ahmed QU, Nasir MHM, Supandi F, Taher M, Saiman MZ. 2021. Preliminary phytochemical screening, in vitro antidiabetic, antioxidant activities, and toxicity of leaf extracts of Psychotria malayana Jack. Plants 10: 1-23.
Njoya EM, Munvera AM, Mkounga P, Nkengfack AE, McGaw LJ. 2017. Phytochemical analysis with free radical scavenging, nitric oxide inhibition antiproliferative activity of Sarcocephalus pobeguinii extracts. BMC Complement Altern Med 17: 1-9.
Oktaviyanti ND, Kartini, Hadiyat MA, Rachmawati E, Wijaya AC, Hayun, Mu’nim A. 2020. A green extraction design for enhancing flavonoid compounds from Ixora javanica flowers using a deep eutectic solvent. R Soc Open Sci 7: 201116.
Pieme CA, Ngoupayo J, Nkoulou CHKK, Moukette BM, Nono BLN, Moor VJA, Minkande JZ, Ngogang JY. 2014. Syzygium guineense extracts show antioxidant activities and beneficial activities on oxidative stress induced by ferric chloride in the liver homogenate. Antioxidant 3: 618-635.
Ragasa CY, Tiu F, Rideout JA. 2004. New cycloartenol esters from Ixora coccinea. Nat Prod Res 18: 319-323.
Ramadhan R, Kusuma IW, Amirta R, Worawalai W, Phuwapraisirisan P. 2018. A new 4-arylflavan from pericarps of Horsfieldia Motleyi displaying dual inhibition against ?-glucosidase and free radicals. Nat Prod Res 32: 2676-2682.
Ramadhan R, Kristanti AN, Amirta R, Kusuma IW, Phuwapraisirisan P, Haqiqi MT, Saparwadi. 2019. Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia. Biodiversitas 20: 1820-1826.
Salhi N, Bouyahya A, Fettach S, Zellou A, Cherrah Y. 2019. Ethnopharmacological study of medicinal plants used in the treatment of skin burns in occidental Morroco (area of Rabat). S Afr J Bot 121: 128-142.
Shaw JE, Sicree RA, Zimmet PZ. 2010. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87: 4-14.
Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, Kumar S, Placido J, Zito SW. ?-Glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki (GK) rats. Carbohydr Res 343: 1278-1281.
Tukiran, Achmad SA, Hakim EH, Makmur L, Sakai K, Shimizu K, Syah YM. 2005. Oligostilbenoids from Shorea balangeran. Biochem Syst Ecol 33: 631-634.

Most read articles by the same author(s)

1 2 > >>