The role of VDR and TNF gene polymorphism in cytokine regulation in type I diabetes mellitus of the Uzbek population, Samarkand, Uzbekistan

##plugins.themes.bootstrap3.article.sidebar##

PDF
DOI https://doi.org/10.13057/biodiv/d250349
Issue
Vol. 25 No. 3 (2024)
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

##plugins.themes.bootstrap3.article.main##

FARIZA RAYIMOVA
Department of Genetics and Biotechnology, Institute of Biochemistry of Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan
GAVHAR DUSHANOVA ♥
Department of Genetics and Biotechnology, Institute of Biochemistry of Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan
BEGALI ALIKULOV
Department of Genetics and Biotechnology, Institute of Biochemistry of Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan
ZAYNITDIN KAMALOV
Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan. Str. Yahyo Gulyamov 74, 100060 Mirabad, Tashkent, Uzbekistan
MALIKA RUZIBAKIEVA
Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan. Str. Yahyo Gulyamov 74, 100060 Mirabad, Tashkent, Uzbekistan
FARANGIZ NABIYEVA
Department of Clinical and Laboratory Diagnostics, Samarkand State Medical University. 18 Amir Temur Str. 140104 Samarkand, Uzbekistan
ASATILLO RAJABOV
Department of Human and Animal Physiology and Biochemistry, Samarkand State University named after Sharof Rashidov. University Boulevard 15, 140104 Samarkand, Uzbekistan

Abstract

Abstract. Rayimova F, Dushanova G, Alikulov B, Kamalov Z, Ruzibakieva M, Nabiyeva F, Rajabov A. 2024. The role of VDR and TNF gene polymorphism in cytokine regulation in type I diabetes mellitus of the Uzbek population, Samarkand, Uzbekistan. Biodiversitas 25: 1329-1336. After 2000, diabetes became one of the most common diseases in the world. Special attention is paid to the research to determine the variability of genetic processes in patients in the origin and development of this disease. The article is devoted to the study of the connection between the polymorphism of genotypes GG, GA, AA polymorphism BsmI of the VDR- (Vitamin D receptor) gene and GG, GA of the TNF-A-308G/A- (Tumor necrosis factor A) gene with the regulation of cytokines TNF? and IL6-Interleykin 6 in sick and healthy individuals of the Samarkand region of the Uzbek population. The analysis of the BsmI polymorphism of the VDR gene and TNF-A-308G/A indicates the involvement of certain genotypes in the Type 1 Diabetes Mellitus (T1DM) pathogenesis. The age of onset of the disease in the studied population is from 7 years, but the increase in the incidence of diseases begins from 10 years. Type 1 diabetes is more common in females. Studies of the relationship between the cytokines TNF? and IL6 show their high content depending on the genotypes GG, GA, and AA of the BsmIA polymorphism of the VDR gene and the genotypes GG and GA of the gene. TNF-A-308G/A. However, the highest rates were recorded in individuals with the AA genotype of the BsmI polymorphism of the VDR gene. The obtained results can serve as fundamental knowledge in revealing and explaining the mechanisms of cytokinin control in people with diabetes in different populations of the same nation.

##plugins.themes.bootstrap3.article.details##

References
Atkinson MA, Eisenbarth GS, Michels AW. 2014. Type 1 diabetes. Lancet 4; 383 (9911): 69-82. DOI: 10.1016/S0140-6736(13)60591-7.
Burrack AL, Martinov T, Fife BT. 2017. T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes. Front Endocrinol (Lausanne): 5 (8): 343. DOI: 10.3389/fendo.2017.00343.
Gaurav G, Terezinha J, Andreoli P, Dinesh KC, Anurag M, Himaja M, Kamal D. 2018. A clinical update on metformin and lung cancer in diabetic patients. Panminerva Med 60(2): 70–75. DOI: 10.23736/S0031-0808.18.03394-3
Hussein AG, Mohamed RH, Alghobashy AA. 2012. Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children. Cell. Immunol 279: 42–45. DOI: 10.1016/j.cellimm. 08.006.
Isailovic N, Daigo K, Mantovani A, Selmi C. 2015. Interleukin-17 and innate immunity in infections and chronic inflammation. J.autoimmun 60: 1–11. DOI: 10.1016/j.jaut.2015.04.006.
Jill MN, Hye-SL, Brittni F, Iris E, Ulla U, Jimin Y, Åke L, Olli S, Jorma T, Marian R, Anette GZ, Jin XS , Suna OG, Wei MC, Stephen SR, Jouko S, Beena A, Jeffrey K, Suvi MV, William H. 2018. Plasma 25-hydroxyvitamin D concentration and risk of islet autoimmunity. Diabetes 67: 146–154. DOI: 10.2337/db17-0802.
Liu Z, Wang H, Yang Z. et al. 2023. Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization study. Cardiovasc Diabetol 22: 236. DOI: 10.1186/s12933-023-01974-6
Loo G, Bertrand MJM. 2023. Death by TNF: a road to inflammation. Nat Rev Immunol 23: 289–303. DOI: 10.1038/s41577-022-00792-3
Maija EM, Melissa CS, Leena K, Valma H, Linnea RH, Irene Y, Heljä MS, Christel LA, Graham AH, Jaakko T. 2017. Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child. PLoS One12(10): e0184942. DOI: 10.1371/journal.pone.0184942
Megha KB, Joseph X, Akhil V, Mohanan PV. 2021. Cascade of immune mechanism and consequences of inflammatory disorders. Phytomedicine 91: 153712. DOI: 10.1016/j.phymed.2021.153712.
Min L, Lu-JS, Xin-YQ. 2014. Advances in the cellular immunological pathogenesis of type 1 diabetes. Cell Mol Med 18(5): 749-58. DOI: 10.1111/jcmm.12270
Narges H, Mahsa MA, Farzaneh A, Ali R, Abbas A, Fatemeh S, Parastoo R, Somayeh PD, Babak S, Aria S. 2019. Role of vitamin D and vitamin D receptor gene polymorphisms on residual beta cell function in children with type 1 diabetes mellitus. Pharmacological Reports. Vol. 71. P. 282–288. DOI: 10.1016/j.pharep.12.012
Pan X, Kaminga AC, Kinra S, Wen SW, Liu H, Tan X, Liu A. 2022. Chemokines in Type 1 Diabetes Mellitus. Front Immunol 15 (12): 690082. DOI: 10.3389/fimmu.2021.690082.
Shcherbak EN. 2011. The role of pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-?) and interleukin-6 (IL-6) in the pathogenesis of diabetic angiopathy. Science and modernity 8(1): 191-195.
Szablewski L. Role of immune system in type 1 diabetes mellitus pathogenesis. 2014. Int Immuno pharmacol 22: 182–91. DOI: 10.1016/j.intimp.2014.06.033
Tapia G, Mårild K, Dahl SR. et al. 2019. Maternal and newborn vitamin D-binding protein, vitamin D levels, vitamin D receptor genotype, and childhood type 1 diabetes. Diabetes Care 42: 553–559. DOI: 10.2337/dc18-2176
Villar-Fincheira P, Sanhueza-Olivares F, Norambuena-Soto I, Cancino-Arenas N, Hernandez-Vargas F, Troncoso R, Gabrielli L, Chiong M. 2021. Role of Interleukin-6 in Vascular Health and Disease. Front Mol Biosci 16 (8): 641734. DOI: 10.3389/fmolb.2021.641734.
Wassmann S, Stumpf M, Strehlow K, Schmid A, Schieffer B, Böhm M, Nickenig G. 2004. Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ. Res 94: 534–541. DOI: 10.1161/01.RES.0000115557.25127.8D.
Xiaoxi M, Zhiguo X, Jiabi Q, Shuoming L, Zhiguang Z. 2020. Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism 105 (11): 3575–3587. DOI: 10.1210/clinem/dgaa525
Yin-LC, Yong-CQ, Yan X, Wei L, Yan-HP, Yong-CH, Li-JG, Hai-LZ, Xiao-XZ. 2017. Serum TNF-? concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: a systematic review and meta-analysis. Immunol Lett 186:52–58. DOI: 10.1016/j.imlet.2017.04.003.

Most read articles by the same author(s)